POLYAZAMACROCYCLIC COMPOUNDS FOR COMPLEXATION OF METAL IONS

摘要

The present invention relates to a new polyazamacrocyclic compound or a salt thereof and its uses as a tissue specific chelator. The compound has formula (I), where x is 2, 3 or a combination of p 2(s) and q 3(s) where p + q = y; y is 3 or 4; R is (CH2)ZP(=O)OR1OR2; R1 is H or CH3; R2 is CnH1+2n; n is 4 to 6; z is 1 to 3. In one important embodiment, this compound may be complexed with a metal to be a plyazamacrocyclic compound-metal complex having formula (II), where r is 2 or 3; and M is a metal ion, including a lanthanide, a heavy metal, or a radionuclide metal.