发明名称 |
PTP-D SUBFAMILY OF PROTEIN TYROSINE PHOSPHATASES |
摘要 |
A novel subfamily (PTP-D) of protein tyrosine phosphatases is identified. Included in this family are PTP-D proteins or glycoproteins having one, two, or three identified amino acid changes in previously defined consensus sequences in the catalytic phosphatase domains of known protein tyrosine phosphatases. The PTP-D proteins or glycoproteins may be produced by recombinant means. Antibodies to PTP-D proteins or glycoproteins and nucleic acid constructs coding therefor, and methods for screening molecules which can bind to PTP-D proteins or glycoproteins and inhibit or stimulate their enzymatic activity, are provided. |
申请公布号 |
WO9403611(A2) |
申请公布日期 |
1994.02.17 |
申请号 |
WO1993EP02086 |
申请日期 |
1993.08.05 |
申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSC |
发明人 |
ULLRICH, AXEL;MOELLER, NILS, PETER, HUNDAHL;BACH-MOELLER, KARIN |
分类号 |
G01N33/53;A61K38/00;A61K38/46;A61K38/55;A61K39/395;A61P35/00;C07H21/04;C12N1/21;C12N5/10;C12N9/16;C12N15/09;C12N15/12;C12N15/55;C12P21/08;C12Q1/42;C12Q1/68;C12R1/19;G01N33/573;G01N33/577 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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