| 摘要 |
PURPOSE:To provide the new compound (and a salt thereof) having lipoperoxide formation-inhibitory activity, useful as a preventive or medicine for various diseases such as arteriosclerosis, hepatopathy and cerebrovascular lesions. CONSTITUTION:The compound of formula I (R<1>-R<4> are each a lower alkyl; ring A is benzene ring substituted with at least one group among lower alkyls, lower alkoxyls and halogens) or a salt thereof, e.g. 5-amino-2-[4-(4- methoxyphenyl)piperidino]methyl-2,4,6,7-tetramethyl-2,3-dihydrobenzofu ran. The compound of the formula I can be obtained, for example, by producing a compound of formula III (X is a halogen or OH) from a compound of formula II followed by reaction of the former compound with a compound of formula IV. The compound of the present invention gives significant antioxidizing activity, being low toxic and having few side effects. |
