发明名称 |
Catalytic reduction of organic carbonyls |
摘要 |
A process is provided whereby organic carbonyl substrates, including esters, ketones and amides, are reduced in a reaction with a silane reducing reagent and a catalyst. Effective catalysts broadly include those which consist of a group 4, 5 or 6 metal which either: a) is in less than its maximum oxidation state or is capable of being converted to a complex in less than its maximum oxidation state; and/or is a group 4, 5 or 6 metal hydride. Exemplary catalysts include titanium-containing catalysts such as (bis trimethylphosphine) titanocene, trimethyl phosphine adduct of a (hydrido) silyl complex of titanocene, titanocene dichloride and titanocene monochloride.
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申请公布号 |
US5286878(A) |
申请公布日期 |
1994.02.15 |
申请号 |
US19900616892 |
申请日期 |
1990.11.21 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
BUCHWALD, STEPHEN L.;KREUTZER, KRISTINA A.;SPALTENSTEIN, ESTHER |
分类号 |
C07B41/02;C07B43/04;C07C29/143;C07C29/147;C07C209/52;C07D207/06;C07D295/023;C07D307/52;(IPC1-7):C07P207/06;C07P207/20;C07C33/22;C07C29/132 |
主分类号 |
C07B41/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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