| 发明名称 |
Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases |
| 摘要 |
This invention relates to certain conjugates of folates and antifolates with difluoroglutamic acid which are useful in the treatment of patients suffering from certain neoplastic diseases including leukemia, melanomas, carcinomas, sarcomas and mixed neoplasias.
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| 申请公布号 |
US5286726(A) |
申请公布日期 |
1994.02.15 |
| 申请号 |
US19900508873 |
申请日期 |
1990.04.12 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN;HEALTH RESEARCH, INC.;MERRELL DOW PHARMACEUTICALS INC. |
发明人 |
BEY, PHILIPPE;COWARD, JAMES K.;MCGUIRE, JOHN J. |
| 分类号 |
A61K31/505;A61K31/517;A61K31/519;A61P35/00;A61P35/02;C07D239/88;C07D239/90;C07D239/94;C07D239/95;C07D471/04;C07D475/08;(IPC1-7):A61K31/505 |
主分类号 |
A61K31/505 |
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