| 发明名称 |
Hybrid oligonucleotide phosphorothioates |
| 摘要 |
The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonueleosides or 2'-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation. |
| 申请公布号 |
AU4780193(A) |
申请公布日期 |
1994.02.14 |
| 申请号 |
AU19930047801 |
申请日期 |
1993.07.22 |
| 申请人 |
WORCESTER FOUND EX BIOLOGY |
发明人 |
METELEV VALERI;AGRAWAL SUDHIR |
| 分类号 |
C12N15/09;A61K31/70;A61K31/7088;A61K31/713;A61K48/00;A61P9/10;A61P9/12;A61P29/00;A61P31/04;A61P31/12;A61P33/02;A61P35/00;C07H21/00;C07H21/02;C07H21/04;C12N15/113;C12Q1/68 |
主分类号 |
C12N15/09 |
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