发明名称 |
2-aminopyrimidinone derivatives |
摘要 |
2-Amino-pyrimidininone derivatives possessing serotonin-antagonistic and anti-histaminic properties. Compositions containing these compounds as the active ingredient. Method of treating subjects suffering from diseases and/or disorders associated with the release of neurotransmitters, in particular, a method of treating subjects suffering form sleep disorders with 2-aminopyrimidinone derivatives substituted with a 4-bis(aryl)methylene-1-piperidinyl group; and a method of treating subjects suffering from psychotic diseases and/or disorders with 2-aminopyrimidinone derivatives substituted with a 4-arylcarbonyl-1-piperidinyl, 4-benzazolyl-1-piperidinyl, 4-benzazolyl-1-piperazinyl or 4-indolyl-1-piperidinyl, 4-benzo(b)furanyl-1-piperidinyl or 4-benzo(b)thienyl-1-piperidinyl group.
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申请公布号 |
US5284854(A) |
申请公布日期 |
1994.02.08 |
申请号 |
US19930082225 |
申请日期 |
1993.06.24 |
申请人 |
JANSSEN PHARMACEUTICA N.V. |
发明人 |
KENNIS, LUDO E. J.;VANDENBERK, JAN;BOEY, JOZEF M. |
分类号 |
C07D401/06;C07D401/14;C07D403/12;C07D409/14;C07D413/12;C07D413/14;C07D417/12;C07D487/04;(IPC1-7):A61K31/505;C07D239/22 |
主分类号 |
C07D401/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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