| 发明名称 |
Process for forming cholesterol lowering compound using pseudodiplodia sp. |
| 摘要 |
This invention relates to a fungal microorganism Pseudodiplodia sp. (MF5767) isolated from bark discs of Hibiscus sp. and useful in a fermentation process to form compounds of formula (I): (* CHEMICAL STRUCTURE *) (I) which are squalene synthetase inhibitors and thus useful as cholesterol lowering agents.
|
| 申请公布号 |
US5284758(A) |
申请公布日期 |
1994.02.08 |
| 申请号 |
US19920929236 |
申请日期 |
1992.08.14 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
BILLS, GERALD F.;OMSTEAD, MARY N.;CLAPP, WENDY H.;PELAEZ, FERNANDO |
| 分类号 |
C12P17/18;(IPC1-7):C12P17/18;C12N1/14;A01N63/00;A61K37/00 |
主分类号 |
C12P17/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
