Butenyl substituted taxanes and pharmaceutical compositions containing them

摘要

Taxane derivatives of the formula <IMAGE> (3) wherein R1 is butenyl, R3 is phenyl, T1 is hydrogen, hydroxyl protecting group, or -COT2, T2 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or monocylic aryl, Ac is acetyl, and E1 and E2 are independently selected from hydrogen and functional groups which increase the water solubility of the taxane derivative are useful as antitumor agents.