发明名称 |
2-substituted amino-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines as antiinflammatory agents |
摘要 |
The present invention is novel compounds which are 2-substituted amino-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are described as having activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever and the like. Thus, the present invention is also a pharmaceutical composition or method of manufacturing a pharmaceutical composition for the use of treating the noted conditions.
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申请公布号 |
US5284949(A) |
申请公布日期 |
1994.02.08 |
申请号 |
US19930029076 |
申请日期 |
1993.03.10 |
申请人 |
WARNER-LAMBERT COMPANY |
发明人 |
BELLIOTTI, THOMAS R.;CONNOR, DAVID T.;KOSTLAN, CATHERINE R. |
分类号 |
C07D239/46;C07D403/12;C07D417/12;(IPC1-7):C07D239/02;A61K31/505 |
主分类号 |
C07D239/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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