| 摘要 |
3- and/or 4-substituted derivatives of quinic acid and a process for the production of 3- and/or 4-substituted derivatives of quinic acid 3- or 4-mono-, 1,3- or 1,4- or even 3,4-disubsti-tuted derivatives of quinic acid are produced by reaction of a hydroxycinnamic acid derivative, of which the phenol group(s) is/are protected with a quinic acid derivative, to form an ester and the different reactivities of the OH functions in the 3 and 4 positions are used to carry out the esterification selectively under low temperature conditions, after which the protective groups are cleaved under controlled acidity and temperature conditions. These conditions avoid any degradation or isomerization. The process enables new quinides to be obtained in high yields.
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