| 摘要 |
PURPOSE: To obtain sufficient reflecting concentration change in a drug concentration range for normal therapy by bringing liquid-like sample containing the drug into contact with drug labeld analogue, and measuring the labeled drug hapten analogue, thereby measuring the drug amount in the liquid. CONSTITUTION: The generation of antibody-drug immune complex is expedited, liquid-like sample containing drug is brought into contact with drug labeled analogue in the presence of antibody for the drug, labeled hapten analogue is measured, and the drug amount in the liquid is measured. The labeled hapten analogue is immunoassay label having amine group, and contains a coupling chain for coupling the 3-place of the drug hapten nucleus to label. Further, the group and cycle of the chain are coupled to one another via chemical group selected from ester represented by a formula I (where Z is O or S), amide represented by a formula II, heteroatom, carbonyl, and the coupling group is except derivatives of monocarboxylic acid having 2 to 12 heteroatoms. The competition immunoassay using such labeled drug hapten analogue indicates sufficient reflecting concentratioh change in a drug concentration range of normal therapy.
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