发明名称 1-AZAADAMANTANE DERIVATIVES AS 5-HT AGONISTS OR ANTAGONISTS
摘要 This invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein Z is selected from the group consisting of (a) and (b), R1 is alkoxy of one to six carbon atoms; R2, R3, R4 and R5 are the same or different and are selected from the group consisting of hydrogen, halogen, CF3, hydroxy, alkoxy of one to six carbon atoms, acyl of two to seven carbon atoms, amino, amino substituted by one or two alkyl groups of one to six carbon atoms, C2-C7 acylamino, aminocarbonyl, aminosulfone optionally substituted by one or two alkyl groups of one to six carbon atoms, C1-C6 alkylsulfone and nitro; m is 1 or 2; X is 0 or NR7; and R7 is hydrogen or alkyl of 1 to 6 carbon atoms.
申请公布号 WO9402482(A1) 申请公布日期 1994.02.03
申请号 WO1993US05945 申请日期 1993.06.25
申请人 G.D. SEARLE & CO. 发明人 FLYNN, DANIEL, LEE;SHONE, ROBERT, L.
分类号 A61K31/435;A61P1/04;A61P1/08;A61P1/12;A61P1/14;A61P25/04;A61P25/20;A61P25/22;A61P25/28;A61P43/00;C07D471/18;(IPC1-7):C07D471/18 主分类号 A61K31/435
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