<p>A method for detecting lymphocyte clonal amplification in a mammal by cloning of lymphocytes so as to identify cell lines expressing a mutation at a structural gene locus and determining the structure of the T-cell receptor in the mutated clonal cell lines. Similar rearrangements of the regions of nucleic acid encoding T-cell receptor among multiple isolated clones from a single individual indicate an in vivo clonal lymphoxyte amplification event.</p>
申请公布号
DE3886511(D1)
申请公布日期
1994.02.03
申请号
DE19883886511
申请日期
1988.06.22
申请人
THE UNIVERSITY OF VERMONT, BURLINGTON, VT., US
发明人
ALBERTINI, RICHARD, J., UNDERHILL CENTER, VT 05490, US