发明名称 BIOLOGICALLY ACTIVE AGENT HAVING IMMUNOMODULATING PROPERTIES, METHOD FOR ITS OBTAINING AND PHARMACEUTICAL PREPARATION BASED ON IT
摘要 A biologically active substance having immunomodulating properties, on the basis of organic compounds of homogenized animal tissue, comprises, thermostable, low-molecular modified components of cell membranes (CCM) with antigenic structure modified in the processes of embryogenesis and/or proliferation and/or differentiation of the cells, and/or pathology preceding and/or accompanying the process of regeneration and/or reparation of the tissue. A method for producing a biologically active substance having immunomodulating properties comprises disintegrating and homogenizing raw material of animal tissue modified, purifying homogenate from non-disintegrated tissue elements by means of filtration and/or centrifugation at about 150 to 250 x g for 10 to 15 min, isolating sediment comprising cell membranes from said homogenate by means of filtration and/or centrifugation, hydrolyzing said sediment, filtering and/ or centrifugating the hydrolysis products at above 1,500 x g for 20 to 40 min, and collecting supernatant of the hydrolysis products comprising CCM as desired product. A preparation for the normalization of physiological state of human and animal organisms consists of a biologically active substance on the basis of organic compounds of homogenized animal tissue, comprising, thermostable. low-molecular modified CCM, taken in an amount of 0.001 to 85.0 per cent by mass with the rest being an excipient. A method for the normalization of physiological state of human and animal organisms containes administering a preparation which consists of a BAS having immunomodulating properties, on the basis of organic compounds of homogenized animal tissue, comprising, thermostable, low-molecular modified CCM, taken in an amount of 0.001 to 85.0 per cent by mass with the rest being an excipient.
申请公布号 CA2149121(A1) 申请公布日期 1994.02.03
申请号 CA19932149121 申请日期 1993.07.20
申请人 NIKOLAENKO ALEXANDR N 发明人 NIKOLAENKO ALEXANDR NIKOLAEVIC
分类号 A61K35/12;A61K38/00;A61K39/00;A61K45/00;C07K2/00;(IPC1-7):A61K35/54;A61K38/02 主分类号 A61K35/12
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