| 摘要 |
Novel compounds are described which are endothelin receptor antagonists, (I) wherein R1 and R2 are independently (a) or (b); R8 is R1, CO2R7, CO2C(R7)O(CO)XR11, PO3(R7)2, SO2NR7R11, CONR7SO2R11, SO3R7, SO2R7, P(O)(OR7)R7, C=N, NR7SO2R11, C(O)N(R6)2 or tetrazole; R10 is H, phenyl, benzyl, radical (b) imidazolyl, thienyl, furyl, pyrazolyl, isoxazolyl, pyridyl or tetrazolyl eventually substituted. R11 is aryl, cycloalkyl, alk(en)yl, alkynyl and the dotted line indicates the optional presence of a double bond or a pharmaceutically acceptable salt thereof. |
