| 摘要 |
<p>Hydroxyphenylthioalkyl amines represented by formula (I), wherein R1 is H or C¿1?-C8 alkyl; R?2¿ is H or C¿1?-C8 alkyl; R?3¿ is H, C¿1?-C8 alkyl or C1-C8 alkanoyl; R?4¿ is H or C¿1?-C8 alkanoyl; Ra is a radioactive material useful in radioimaging and/or radiochemotherapy where the dottet line (---) indicates: 1) Ra is covalently bound to the structure of formula (I); 2) Ra is ionically associated with the structure of formula (I); 3) Ra is radioactive carbon which is part of the structure of formula (I); and x is 1 to 5, with the provisos that when x is 1, one of R1, R2 or R3 is other than H, and that the sulphur containing group and the Ra group are in the 2, 4 or 6 positions of the phenyl ring, are useful in radioimaging and radiotherapy. Preferred compounds for use in radioimaging are N-acetyl-4-S-cysteaminylphenol and N-[2-[(4'-acetoxyphenyl)thio]ethyl]acetamide. The O-acylated derivatives are novel and are also useful in treatment of pigment disorders.</p> |
