PSEUDO-HALF-KNOT RNA FORMATION BY HYBRIDIZATION OF ANTISENSE OLIGONUCLEOTIDES TO TARGET RNA'S SECONDARY STRUCTURE

摘要

Compositions and methods for modulating the activity of RNA are provided. Oligonucleotides are hybridized with an RNA structure to form a stable heteroduplex so that the RNA is no longer recognized by its regulatory protein after oligonucleotide binding. Reactive moieties can be tethered to the oligonucleotide that enhance its activity. Antisense oligonucleotides directed against HIV TAR are provided.