| 发明名称 |
AMINO ACID LINKED NITROGEN MUSTARD DERIVATIVES AND THEIR USE AS PRODRUGS IN THE TREATMENT OF TUMOURS |
| 摘要 |
Prodrugs, of generic formula (I), are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalysed reactions, wherein R1 and R2 each independently represents chlorine, bromine, iodine, OSO2Me, or OSO2phenyl, X represents O, NH or -CH2-; Y represents O. |
| 申请公布号 |
WO9402450(A1) |
申请公布日期 |
1994.02.03 |
| 申请号 |
WO1993GB01560 |
申请日期 |
1993.07.23 |
| 申请人 |
ZENECA LIMITED;CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED |
发明人 |
BURKE, PHILIP, JOHN;DOWELL, ROBERT, IAN;MAUGER, ANTHONY, BRIAN;SPRINGER, CAROLINE, JOY |
| 分类号 |
A61K31/17;A61K31/195;A61K31/27;A61K31/41;A61K39/395;A61K45/00;A61K47/48;A61P35/00;A61P43/00;C07C237/20;C07C237/40;C07C269/04;C07C271/54;C07C275/24;C07C275/40;C07C275/42;C07C309/66;C07C309/69;C07C309/72;C07C311/51;C07C317/50;C07C323/58;C07D257/04 |
主分类号 |
A61K31/17 |
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