PROCESS FOR THE MANUFACTURE OF DISODIUM 3-AMINO-1-HYDROXYPROPANE-1,1-DIPHOSPHONATE IN CRYSTALINE FORM

摘要

The invention relates to a novel crystal modification, containing water of crystallization, of disodium 3-amino-1-hydroxypropane-1,1-diphosphonate of the formula and to a process for the manufacture thereof. This modification is suitable for the oral treatment of disorders of the calcium and phosphate metabolism and associated diseases in warm-blooded animals.