发明名称 |
ADENOSINE RE-UPTAKE INHIBITING DERIVATIVES OF DIPHENYL OXAZOLES, THIAZOLES AND IMIDAZOLES |
摘要 |
A series of 1-piperazinyl-N-phenylacetamide derivatives of 4,5-diphenyl-oxazoles, thiazoles, and imidazoles which are novel adenosine transport inhibitors have been found to provide effective antiischemic protection for CNS tissue, particularly neurons. A method of treatment to protect against CNS ischemia, such as that resulting from trauma, stroke, or other ischemic conditions, comprises administration of these novel compounds to an individual in need of such treatment.
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申请公布号 |
CA2101311(A1) |
申请公布日期 |
1994.02.01 |
申请号 |
CA19932101311 |
申请日期 |
1993.07.26 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
BALASUBRAMANIAN, NEELAKANTAN |
分类号 |
A61K31/495;A61K31/496;A61P9/00;A61P9/10;A61P25/00;C07D233/54;C07D233/64;C07D235/06;C07D235/14;C07D263/32;C07D263/48;C07D263/56;C07D263/58;C07D277/22;C07D277/28;C07D277/42;C07D277/64;C07D403/06;C07D413/04;C07D413/06;C07D417/06;C07D471/08;C07D487/08;(IPC1-7):C07D413/02;C07D403/02;C07D417/02 |
主分类号 |
A61K31/495 |
代理机构 |
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地址 |
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