PHENOXYETHYLAMINE DERIVATIVES, PROCESS FOR PREPARING THE SAME, AND COMPOSITION FOR EXHIBITING EXCELLENT –_-BLOCKING ACTIVITY CONTAINING THE SAME

摘要

Phenoxyethylamine derivatives represented by the general formula (I): <IMG> (I) wherein R1 and R5 represent lower-alkyl, R2 and R3, which may be the same or different, each represents hydrogen or lower-alkyl, or <IMG> represents a 5- or 6-membered ring system which may include nitrogen, oxygen or sulfur as a ring membered atom, R4 represents hydrogen or lower-alkyl, and n represents an integer selected from 1 to 3, their optical isomers and pharmacologically-acceptable acid addition salts, which exhibit excellent .alpha.1 blocking activity, a process for their preparation, pharmaceutical compositions thereof; and a method for the treatment of a subject afflicted with hypertension or dysuria by administrating such a compound, are all disclosed.