发明名称 |
Intermediates for conjugation of polypeptides with high molecular weight polyalkylene glycols |
摘要 |
A biologically persistent, water-soluble, substantially non-immunogenic, substantially non-antigenic conjugate of superoxide dismutase is prepared by coupling one to five strands of a polyalkylene glycol which is polyethylene glycol or polyethylene-polypropylene glycol copolymer, wherein said polyalkylene glycol has an average molecular weight of about 35,000-1,000,000.
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申请公布号 |
US5283317(A) |
申请公布日期 |
1994.02.01 |
申请号 |
US19910774841 |
申请日期 |
1991.10.11 |
申请人 |
DDI PHARMACEUTICALS, INC. |
发明人 |
SAIFER, MARK;SOMACK, RALPH;WILLIAMS, L. DAVID |
分类号 |
A61K38/44;A61K47/48;C12N9/96;C12N11/08;(IPC1-7):C07D207/46;C08G59/00 |
主分类号 |
A61K38/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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