发明名称 |
Method for reducing insulin resistance in mammals |
摘要 |
A method for administering pyruvate is disclosed which comprises administering a therapeutically effective amount of a pyruvate precursor to a mammal in the form of pyruvamide or a pyruvyl-amino acid. The pyruvyl-amino acid is preferably selected from the group comprising pyruvyl-glycine, pyruvyl-alanine, pyruvyl-leucine, pyruvyl-valine, pyruvyl-isoleucine, pyruvylphenyl al anine, pyruvyl-proline and pyruvyl-sarcosine, and their amides and esters as well as their salts. Associated with the administration of a pyruvate precursor to a mammal in accordance with this invention are improved insulin resistance, lower fasting insulin levels, and reduced fat gain. Novel methods of synthesizing several pyruvate precursors are also disclosed.
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申请公布号 |
US5283260(A) |
申请公布日期 |
1994.02.01 |
申请号 |
US19930043720 |
申请日期 |
1993.04.08 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
MILLER, ROBERT H.;PARLET, NICKKI L.;CIPOLLO, KENT L.;DHAON, MADHUP K.;HOUBION, JOHN A.;LUNDELL, EDWIN O. |
分类号 |
A61K31/19;A61K31/195;A61K31/40;A61P3/04;C07C231/02;C07C235/72;(IPC1-7):A61K31/195 |
主分类号 |
A61K31/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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