C-BONDED PYRAZOLE DERIVATIVE

摘要

The invention provides compounds of the general formula (I): or a physiologically acceptable salt, solvate (e.g. hydrate) or a metabolically labile ester thereof in which R<1> represents a hydrogen atom or a group selected from C1-6alkyl or C2-6alkenyl; R<2> represents a hydrogen atom or a group selected from C1-6alkyl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, C3-6alkenyl, fluoroC1-6alkyl, fluoroC3-6alkenyl, phenyl, -(CH2)kCOR<5> or -(CH2)kSO2R<5>; R<3> represents a hydrogen atom or a group selected from C1-6alkyl optionally substituted by a hydroxy or C1-6alkoxy group, C2-6alkenyl, fluoroC1-6alkyl, -(CH2)mR<6>, -(CH2)nCOR<7> or -(CH2)pNR<8>COR<9>; R<4> represents a group selected from -CO2H, -NHSO2CF3 or a C-linked tetrazolyl group; R<5> represents a group selected from C1-6alkyl, C2-6alkenyl, C1-6alkoxy or the group -NR<1><0>R<1><1>; R<6> represents a phenoxy or benzyloxy group; R<7> represents a hydrogen atom or a group selected from hydroxy, C1-6alkyl, C1-6alkoxy, phenyl, phenoxy or the group -NR<1><0>R<1><1>; R<8> represents a hydrogen atom or a C1-6alkyl group; R<9> represents a hydrogen atom or a group selected from C1-6alkyl, C1-6alkoxy, phenyl, benzyl, phenoxy or the group -NR<1><0>R<1><1>; R<1><0> and R<1><1> which may be the same or different each independently represent a hydrogen atom or a C1-4alkyl group or -NR<1><0>R<1><1> forms a saturated heterocyclic ring which has 5 or 6 ring members and may optionally contain in the ring one oxygen atom; k represents zero or an integer from 1 to 4; m represents an integer from 1 to 4; n represents zero or an integer from 1 to 4; and p represents an integer from 1 to 4. The compounds may be used in the treatment or prophylaxis of hypertension and diseases associated with cognitive disorders.