发明名称 |
A drug delivery device and a method of making such device |
摘要 |
A drug delivery device comprising a polymer matrix and a drug contained in or surrounded by the matrix which polymer matrix is a cross-linked hydrogel matrix comprising a dextranase degradable polymer and a cross-linking agent providing covalent bonded network linkage between the polymer chains. The device is suitable for delivering drug to the colon. A method of making the device comprising: (a) dissolving a dextranase degradable polymer in a solvent; (b) adding a cross linking agent capable of cross-linking the polymer with covalent bonds to the solution; (c) allowing the cross-linking agent to react with the dextranase degradable polymer to provide a cross-linked hydrogel matrix, and loading the drug into said solution before or after the reaction between the polymer and the cross-linking agent has finished. |
申请公布号 |
AU4417893(A) |
申请公布日期 |
1994.01.31 |
申请号 |
AU19930044178 |
申请日期 |
1993.07.06 |
申请人 |
HELLE BRONDSTED |
发明人 |
HELLE BRONDSTED;LARS HOVGAARD |
分类号 |
A61K9/00;A61K9/20;A61K9/22;A61K47/36 |
主分类号 |
A61K9/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|