| 摘要 |
PCT No. PCT/GB93/01415 Sec. 371 Date Jan. 13, 1995 Sec. 102(e) Date Jan. 13, 1995 PCT Filed Jul. 6, 1993 PCT Pub. No. WO94/01402 PCT Pub. Date Jan. 20, 1994Compounds of formula (I), and salts and prodrugs thereof, wherein Q1 is phenyl substituted by one or more halo; optionally substituted naphthyl, indolyl, benzothiophenyl, benzofuranyl, benzyl or fluorenyl; the dotted line represents an optional covalent bond; one of X and Y is H and the other is hydroxy or C1-6alkoxy, or X and Y together form a group =O or =NOR5 where R5 is H or C1-6alkyl; R1 is H or C1-6alkyl. R2 is CO-W-R6 where W represents a bond or a hydrocarbon chain of 1-6 carbon atoms and R6 is an azacyclic or azabicyclic group; R3 is H, C1-6alkyl or C2-6alkenyl; and R4 is phenyl optionally substituted by 1-3 of C1-6 alkyl, C2-6alkenyl, C2-6alkynyl, halo, cyano, nitro, trifluoromethyl, trimethylsilyl, ORa, SRa, SORa, NRaRb, NRaCORb, NRaCO2Rb, CO2Ra or CONRaRb, where Ra and Rb are H, C1-6alkyl, phenyl or trifluoromethyl; are tachykinin antagonists useful in therapy. |
