Oral compsn. for treating periodontal disease - contg. antibody obtd. by immunising animal with surface polysaccharide from pathogenic bacteria

摘要

Oral compsn. contains an antibody (AB) obtd. by immunising an animal with an antigen (AG) including at least one polysaccharide (I) from the surface layer of bacteria associated with periodontal disease. AG pref. consists of (I) or a conjugate of (I) with a polypeptide. The compsn. pref. contains 0.0002-10 wt.% of AB. USE/ADVANTAGE - AB are used for prophylaxis or therapy of periodontal disease caused by Actinobacillus actinomycetemcomitans (ABAMC), Porphyrosmonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, Capnocytophaga spp., Eikonella corrodens, Wolinella recta, Bacetroides forsythus and spirochaetes (e.g. Treponema denticola), by inhibiting colony formation on oral surfaces. AB are highly specific for the required pathogenic bacterial strains, and can be prepd. with high productivity. Daily dosage of AB is 0.0001-50 g/kg. AB may be used in oral compsns. (e.g. toothpaste, mouthwash or chewing gum). Alternatively, AB-contg. products (e.g. milk or eggs) from immunised animals can be used in or as foods.