| 摘要 |
PCT No. PCT/GB90/02028 Sec. 371 Date Jun. 18, 1991 Sec. 102(e) Date Jun. 18, 1991 PCT Filed Dec. 27, 1990 PCT Pub. No. WO91/09603 PCT Pub. Date Jul. 11, 1991.The invention relates to N-deacetyl-lysogangliosides and physiologically acceptable salts thereof, especially those of formula (I): (* CHEMICAL STRUCTURE *) (I) wherein R represents -CH=CH(CH2)nCH3 or -CH2CH2(CH2)nCH3; n is 12 or 14; R1 represents (* CHEMICAL STRUCTURE *) (* CHEMICAL STRUCTURE *) or hydrogen; and R2 represents hydrogen or acetyl; for use in therapy. The compounds are useful as inhibitors of phospholipases A2, and of superoxide production, as antiproliferative and immunosuppressant agents in the treatment of autoimmune diseases. The invention also relates to the use of N-deacetyl-lysogangliosides for the manufacture of medicaments for the treatment of the aforementioned conditions.
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