Novel semi-synthetic cephalosporin derivatives having a fused pyridiniummethyl at 3-position of the cephem nucleus, pharmaceutically acceptable salts, physiologically hydrolizable esters or solvates thereof are disclosed. Also disclosed is a process for preparing the cephalosporin derivatives which comprises introducing a fused pyridiniummethyl substituent at 3-position of 7-(beta)-((Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido)-3-cephem-carboxylic acid derivatives. The compounds of the present invention show potent antibacterial activities and a broad spectrum against both gram-positive and gram-negative bacteria.
申请公布号
US5281589(A)
申请公布日期
1994.01.25
申请号
US19920896667
申请日期
1992.06.10
申请人
CHEIL FOODS & CHEMICALS, INC.
发明人
KIM, CHOONG S.;AN, SEUNG H.;CHO, SUNG K.;AHN, YANG S.;CHOI, KYOUNG E.;KIM, JE H.;YUN, ROK L.;PARK, SUNG Y.;YOON, YEO H.;LYU, CHUN S.;LEE, KOUN H.