发明名称 REGULATION OF CELL PROLIFERATION AND DIFFERENTIATION USING PEPTIDES
摘要 Methods, including a method of inhibiting proliferation and enhancing differentiation of a mammalian cell involving bringing the cell into contact with a peptide which has 10% or greater homology with a region of human parathyroid hormone or human hypercalcemic factor and which is capable of enhancing the differentiation or inhibiting the proliferation in vitro of cultured human keratinocytes. Also disclosed is a method of inducing proliferation of a mammalian cell including bringing the cell into contact with a peptide which has 10% or greater homology with a region of human parathyroid hormone or human hypercalcemic factor and which is capable of blocking the inhibition of proliferation or stimulation of differentiation in vitro, of cultured human keratinocytes by PTH (1-34), 1,25(OH)2D3, or CFF (1-34).
申请公布号 CA1326460(C) 申请公布日期 1994.01.25
申请号 CA19880580558 申请日期 1988.10.19
申请人 HOLICK, MICHAEL F. 发明人 HOLICK, MICHAEL F.
分类号 A61K38/00;A61K38/23;A61K38/29;A61P5/00;A61P17/00;A61P17/16;A61P35/00;A61P43/00;C07K14/575;C07K14/635;C12N5/02;C12N5/071;C12R1/91;(IPC1-7):C12N5/00;A61K37/24 主分类号 A61K38/00
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