ECHOGRAPHIC CONTRAST AGENT COMPOSITION

摘要

Micro-gas bubble compositions reconstitutable in aqueous systems and useful as echographic contrast agents are prepared by lyophilising aqueous emulsions which contain parenterally acceptable emulsifiers, apolar liquids and lipid-soluble or water-insoluble builders. These lyophilisates are characterised by a remarkable storage stability and when reconstituted with water they produce microbubble-containing echographic contrast agents characterised by microbubbles having a very small diameter and a surprisingly high stability.