| 摘要 |
<p>Therapeutic physiologically acceptable mixtures comprising PQQ and a reducing agent or agents characterized by a net reducing capacity greater than the oxidizing capacity of PQQ originally in the mixture. The reducing agent(s) is present in substantial molar excess of the PQQ. Kits for forming such mixtures are also disclosed comprising a supply of PQQ stably maintained in reduced form, and a supply of the reducing agent(s), separately packaged from the supply of PQQ. The preferred reducing agent is ascorbate. Other reducing agents include anionic -ene diols, thiols, sulfhydryl-containing amino acids. Specific reducing agents include TironR, mercaptosuccinate, D-penicillamine, glycine and dopamine. Also disclosed are methods for treating a PQQ-responsive condition in a mammalian patient, comprising administering to the mammal a composition comprising PQQ and the reducing agent(s).</p> |
