| 摘要 |
Heterocyclic amine-borane compounds of formula (I) wherein: A is a heterocyclic amine moiety; R1 is selected from H, alkyl, alkylaryl, aryl, and arylalkyl; and R2 is selected from CN, COOH, COOR3, and CONHR3 where R3 is selected from H, alkyl, alkylaryl, aryl, aralkyl. The heterocyclic amine-borane compounds of the invention are bioactive in character, variously exhibiting anti-tumor, anti-inflammatory, and anti-hyperlipidemic activity. The invention also comprehends a method of inhibiting enzyme activity (e.g., DNA topoisomerase II, PRPP amidotransferase, IMP dehydrogenase, dihydrofolate reductase, and/or ribonucleotide reductase) in an in vitro or in vivo system, comprising administering to the system an enzyme-inhibitingly effective amount of a Lewis-base borane adduct, such as a heterocyclic amine-borane compound of the foregoing formula.
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