发明名称 |
Non-anticoagulant heparin derivatives |
摘要 |
A non-anticoagulant (NAC) form of heparin which shows antiproliferative activity with respect to smooth muscle cells is useful in the prevention of restenosis and other conditions benefited by antiproliferative activity with respect to smooth muscle cells. This NAC form of heparin is prepared by oxidizing heparin/heparan sulfate to a desired level with periodate followed by reduction of the resulting aldehyde groups; all under conditions which prevent depolymerization of the heparin.
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申请公布号 |
US5280016(A) |
申请公布日期 |
1994.01.18 |
申请号 |
US19910753299 |
申请日期 |
1991.09.03 |
申请人 |
GLYCOMED INCORPORATED |
发明人 |
CONRAD, H. EDWARD;GUO, YUCHUAN |
分类号 |
A61K39/395;A61K31/715;A61P43/00;C07K16/18;C07K16/36;C08B;C08B37/00;C08B37/10;(IPC1-7):A61K31/725 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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