Nuclear factors associated with transcriptional regulation.

摘要

Trans-acting factors that mediate B cell specific transcription of immunoglobulin (Ig) genes have been postulated based on an analysis of the expression of exogenously introduced Ig gene recombinants in lymphoid and non-lymphoid cells. Two B cell-specific, cis-acting transcriptional regulatory elements have been identified. One element is located in the intron between the variable and constant regions of both heavy and Kappa light chain genes and acts as a transcriptional enhancer. The second element is found upstream of both heavy chain and Kappa light chain gene promoters. This element directs lymphoid-specific transcription even in the presence of viral enhancers.