| 发明名称 |
Process for the preparation of 2-fluoro-9-(2,3,5-tri-O-benzyl-beta-arabinofuranozyl)adenine. |
| 摘要 |
<p>A process for the preparation of 2-fluoro-9-(2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl)adenine (I) is described. The process involves reacting a protected 2-fluoro adenine with a protected chlorosugar under controlled conditions of temperature (80-85 DEG C) to produce (I), rather than using a process involving fluorinating a 2-substituted nucleoside precursor of (I).</p> |
| 申请公布号 |
EP0578208(A1) |
申请公布日期 |
1994.01.12 |
| 申请号 |
EP19930110800 |
申请日期 |
1993.07.06 |
| 申请人 |
ASH STEVENS, INC. |
发明人 |
MARKOVAC, ANICA;KALAMAS, RICHARD L.;LAMONTAGNE, MAURICE P. |
| 分类号 |
C07H19/16;C07D473/34;C07F7/12;C07F9/6561;C07H19/19;(IPC1-7):C07H19/19;A61K31/70 |
主分类号 |
C07H19/16 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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