| 摘要 |
Described are the new antibiotic substance libanomycin, consisting of libanomycin A, libanomycin B and libanomycin C, and a process for the preparation thereof. The process is characterized in that a new microorganism of the species Streptomyces libani n.sp. is grown under aerobic conditions in a liquid cultural medium containing a source of carbon, of nitrogen and mineral salts, at a temperature of from 22 DEG to 37 DEG C, for a period of from 72 to 160 hours, at a pH of from 5 to 8.8. The antibiotic complex libanomycin thus obtained is isolated from the fermentation broth by extraction with suitable solvents and precipitation therefrom. The antibiotic complex may be separated in the three forms libanomycin A, libanomycin B and libanomycin C by column chromatography. The microorganisms used in the process have been designated as Streptomyces libani n. sp. F.I. 2343, Streptomyces libani n.sp. F.I. 2399, Streptomyces libani n.sp. F.I. 2501, Streptomyces libani n.sp. F.I. 2521 and have been deposited at the Institute of Microbiology of the Rutger University receiving the index numbers I.M.R.U. 3915, I.M.R.U. 3916, I.M.R.U. 3917, I.M.R.U. 3918. |
