发明名称 |
Biodegradable in-situ forming implants and methods of producing the same |
摘要 |
A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.
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申请公布号 |
US5278202(A) |
申请公布日期 |
1994.01.11 |
申请号 |
US19910788159 |
申请日期 |
1991.12.23 |
申请人 |
ATRIX LABORATORIES, INC. |
发明人 |
DUNN, RICHARD L.;ENGLISH, JAMES P.;COWSAR, DONALD R.;VANDERBILT, DAVID D. |
分类号 |
A61L27/00;A61F2/00;A61F2/02;A61F2/30;A61K9/00;A61K9/22;A61K47/34;A61L15/44;A61L15/62;A61L24/00;A61L24/04;A61L24/06;A61L26/00;A61L27/16;A61L27/18;A61L27/26;A61L27/34;A61L27/50;A61L27/54;A61L27/58;(IPC1-7):C08L67/00;C08L69/00;C08L77/00 |
主分类号 |
A61L27/00 |
代理机构 |
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代理人 |
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地址 |
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