PROCESS FOR THE PREPARATION OF 5-(TRIFLUOROMETHYL)- URACIL, AND THE NOVEL COMPOUNDS, 2,4-DICHLORO-5- TRICHLOROMETHYL-PYRIMIDINE AND 2,4-DIFLUORO-5- TRIFLUORO-METHYL-PYRIMIDINE

摘要

Process for the preparation of 5-(trifluoromethyl)-uracil, and the novel compounds 2,4-dichloro-5-tri-chloromethyl-pyrimidine and 2.4-difluoro-5-trifluoro-methyl-pyrimidine 5-Trifluoromethyl-uracil is obtained by chlorinating thymine under mild conditions, further chlorinating the resulting 2,4-dichloro-5-methyl-pyrimidine under drastic conditions to give 2,4-dichloro-5-trichloromethyl-pyrimidine, reacting the latter with a fluorinating agent to give 2,4-fluorinated and/or -chlorinated 5- trifluoromethylpyrimidines and subjecting these to hydrolysis. The novel chemical compounds 2,4-dichloro- 5-trichloro-methylpyrimidine and 2,4-difluoro-5-trifluoromethyl-pyrimidine are obtained in the course of this process.