| 摘要 |
<p>An Interleukin-1β deletion mutant, which has a quasi conserved sequence of three amino acids deleted from the amino acid sequence of an endogenous mammalian Interleukin-1β is disclosed. The deletion is Ser Asn Asp (numbers 52-54 of mature human IL-1β) in the case of human, mouse, rat and rabbit, and Arg Asp Asn in the case of bovine and sheep Interleukin-1β. The Interleukin-1β deletion mutant is shown to be an Interleukin-1 receptor ligand which binds to both Interleukin-1 type I receptors and Interleukin-1 type II receptors with substantially different binding-affinities. The ligand may have additional amino acid deletion(s) and/or point mutation(s). The Interleukin-1β deletion mutants may be used as carriers and adjuvants for biologically active molecules as well as in therapeutic and/or prophylactic agent.</p> |
