ANTI-HIV PEPTIDE OR PEPTIDE DERIVATIVE

摘要

A peptide or a peptide derivative represented by the following sequence (1), or a peptide or a peptide derivative wherein at least one amino acid in the sequence (1) is a D-amino acid, and a dimer thereof. In the sequence (1): R1-Asp Thr Ser Glu Asp Glu Val Ile Glu Lys Ile Leu Lys Asn Cys(R2) Lys Ile Gln Ile Glu Leu Asp Pro X Phe Glu Asn-R3, R1 represents hydrogen, a cysteine residue or an N-terminus-modifying group; R2 represents hydrogen or a cysteine-modifying group; R3 represents hydroxy, a cysteine residue or a C-terminus-modifying group; and X represents a tyrosine residue or a valine residue. The peptide or peptide derivative inhibits the infection with human immunodeficiency virus (HIV) and the formation of multinucleated giant cells after the infection with HIV, thus being usable for treating and preventing acquired immunodeficiency syndrome.