发明名称 |
TRIVALENT SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING STEREOSPECIFIC ALKYLPHOSPHONATES AND ARYLPHOSPHONATES |
摘要 |
The present invention provides a method for making R stereospecific alkyl- and aryl-phosphonate linkages between nucleotides. These methods can be used for automated synthesis of oligonucleotides having sequential R stereospecific alkyl- and aryl-phosphonate linkages. The present invention is also directed to the oligonucleotides having several sequential R phosphonate linkages which were produced by the subject methods. Moreover, the present invention provides methods for using the subject oligonucleotides, including methods for regulating the biosynthesis of a DNA, an RNA or a protein and methods for detecting and isolating complementary nucleic acid targets. |
申请公布号 |
WO9400472(A2) |
申请公布日期 |
1994.01.06 |
申请号 |
WO1993US06251 |
申请日期 |
1993.06.30 |
申请人 |
RESEARCH CORPORATION TECHNOLOGIES, INC. |
发明人 |
WICKSTROM, ERIC;RIFE, JASON, P. |
分类号 |
C07H21/00;C12N15/113 |
主分类号 |
C07H21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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