发明名称 |
NOVEL CRYSTAL OF MONOHYDRATE OF HETEROCYCLIC BIS(PHOSPHONIC ACID) DERIVATIVE |
摘要 |
Crystal D or E of 1-hydroxy-2-(imidazo[1,2-a]-pyridin-3-yl)ethane-1,1-bis(phosphonic acid) monohydrate having specified lattice spacing and relative intensity in the powder X-ray diffraction spectrum obtained by using Cu-K alpha radiation and a dehydration peak temperature of 135-149 DEG C or 160-170 DEG C according to TG-DSC thermogravimetric analysis; and a solid pharmaceutical preparation containing the same. The crystals are useful for producing a stable solid preparation of the above compound which has an excellent drug efficacy for diseases wherein increased bone resorption participates, such as osteoporosis. |
申请公布号 |
WO9400462(A1) |
申请公布日期 |
1994.01.06 |
申请号 |
WO1993JP00821 |
申请日期 |
1993.06.18 |
申请人 |
YAMANOUCHI PHARMACEUTICAL CO., LTD. |
发明人 |
ISOMURA, YASUO;TAKEUCHI, MAKOTO;HAMADA, MAMORU;KANEKO, YOSHISABURO;YAMAMOTO, NORIYA |
分类号 |
A61K31/675;C07F9/6561;(IPC1-7):C07F9/656 |
主分类号 |
A61K31/675 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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