New mistletoe lectin - with immunomodulatory activity, useful for cancer adjuvant therapy

摘要

A new galactoside-specific lectin (ML-1) isolated biochemically from an aq. mistletoe extract comprises protein chains, one of which is responsible for immunomodulatory activity by modifying intra- and intercellular biosignal chains, this activity being achievable in vivo only at a low dose in the nanogram range by increasing cytokine secretion and other cellular immunological parameters, on the basis of which it may be used for supportive (palliative) therapy in oncology. USE - ML-1 may be used for adjuvant therapy in the surgical, chemotherapeutic and radiotherapeutic treatment of cancer.