Cytotoxins specific for gm-csf receptor-bearing cells

摘要

Conjugates containing granulocyte-macrophage colony-stimulating factor (GM-CSF) conjugated to a toxic molecule are provided. The conjugates are used for ameliorating GM-CSF-mediated or GM-CSF-associated disorders, including cancers and inflammatory disease. In a preferred embodiment, GM-CSF is chemically conjugated by disulfide bonds to the ribosome-inactivating protein saporin. The resulting conjugate is highly toxic to targeted cells.