| 摘要 |
PURPOSE:To obtain the titled almost novel compound which is an intermediate for antimicrobial agents beta-lactam compounds, by reacting 2,3-epoxybutyramide having protected amino group as a raw material with formalin, etc., and further reacting the resultant compound with an arylsulfinic acid. CONSTITUTION:A compound expressed by formula I (R<1> is a protecting group of the amino group), e.g. (2R,3R)-N-(p-methoxybenzyl)-2,3-epoxybutyramide, is reacted with formalin or an acyloxymethyl halide to give a compound expressed by formula II (R<2> is H or acyl), which is reacted with an arylsulfinic acid, e.g. benzenesulfinic acid, to afford an amide compound expressed by formu la III (R<3> is aryl which may have a substituent group), e.g. (2R,3R)-N-(2,4- dimethoxybenzyl)-N-phenylsulfonylmethyl-2,3-epoxybutyramide. Compounds except a compounds expressed by formulas II and III (R<1> is aryl) are novel. |
