| 摘要 |
<p>This invention relates to the identification of critical amino acid residues in the 6-EGF region of thrombomodulin [TM]. Modification of these residues has a predictable effect on the ability of TM to modify cofactor activity, e.g., bind to thrombin and/or to mediate potentiation of thrombin mediated activation of protein C.</p> |
