METHODS AND COMPOSITIONS FOR INHIBITING ENDOTHELIAL CELL AND FIBRINOGEN MEDIATED INFLAMMATION
摘要
The present invention contemplates therapeutic compositions containing a fibrinogen homolog capable of binding to endothelial cells in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Also described are therapeutic compositions containing an ICAM-1 homolog capable of binding to fibrinogen in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Methods of inhibiting endothelial cell and fibrinogen mediated inflammation within a patient by administering a homolog of this invention are also contemplated.
申请公布号
WO9325218(A1)
申请公布日期
1993.12.23
申请号
WO1993US05610
申请日期
1993.06.11
申请人
THE SCRIPPS RESEARCH INSTITUTE
发明人
LANGUINO, LUCIA, R.;ALTIERI, DARIO, C.;PLOW, EDWARD, F.;GELTOSKY, JOHN, E.