发明名称 |
VECTOR PARTICLES RESISTANT TO INACTIVATION BY HUMAN SERUM |
摘要 |
A retroviral vector particle resistant to inactivation by human serum. The vector particles preferably include p15E protein wherein at least a portion of the DNA encoding p15E protein is mutated such that the vector particle is resistant to inactivation by human serum. The vector particles may further include a protein containing a receptor binding region which binds to the receptor of a human target cell, thereby enabling the direct introduction of desired heterologous genes in vivo, whereby the vector particle including the heterologous gene travels directly to a targeted cell or tissue. |
申请公布号 |
WO9325698(A1) |
申请公布日期 |
1993.12.23 |
申请号 |
WO1993US04706 |
申请日期 |
1993.05.14 |
申请人 |
THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE |
发明人 |
ANDERSON, W., FRENCH;MASON, JAMES, M. |
分类号 |
C12N15/09;A61K38/00;C07K14/15;C12N5/10;C12N7/00;C12N15/867;(IPC1-7):C12P21/06;C12N5/00;C07K15/00;C07K13/00;C07K3/00;C12N15/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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